The purpose of this study was to prepare a bilayer gastro retentive tablet of nizatidine using direct compression technology and optimize the type and concentration of polymer to give maximum retentive effect with good drug release profile. Nizatidine is having biological half life of 1-2 hr was selected as model drug, as it is competitive inhibitor of histamine at H2- receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced having first pass metabolism, low oral bioavailability, maximum absorption in the upper part of GIT hence it is suitable for gastro retentive system. In this study, a bilayer tablet was prepared which contains an immediate release portion and a floating layer. Immediate release of drug was controlled by superdisintegrant sodium starch glycolate, crosspovidone and microcrystalline cellulose. For sustain release layer various hydrophilic and hydrophobic polymers such as HPMC and carbomer were used. Sodium bicarbonate and citric acid used as gas generating agent. The bilayer tablets were characterized by lag time, floating time, weight variation, drug content and dissolution profile. It was concluded on the basis of buoyancy and in-vitro release kinetics that optimized formulation N-3 gave the best in-vitro release of 91.23% in 12 hrs was carried out in 1.2 pH.
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